Lisa Marie Simpson, voiced by Yeardley Smith, is Homer and Marge's oldest duaghter and the middle child on The Simpsons.  Lisa is very intelligent, plays the saxophone, is a vegetarian, Buddhist, and definitely a bit of a young political activist.  She's basically the complete opposite of her brother, Bart.

Lisa Simpson Quotes

Lisa: You're all forgetting the most important thing! Which is that it's wrong to imprison an animal!
Homer: Lisa, go to your room.

Bret: She can't hear us. We're stage whispering.
Lisa: I can hear you.
Jermaine: No you can't!

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The Simpsons Quotes

Comic Book Guy: You are acceptable!
Homer: Great, would you like to see me naked?
Studio Exec: Oh, there's no nudity in this movie
Homer: What movie?

I played hardball with hollywood, the closest i will ever come to playing a sport in my life

Comic Book Guy